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We report two patients with intracranial mass lesions, both treated with initial external-beam cranial irradiation (EBRT), subsequent linear accelerator-based stereotactic irradiation, and chemotherapy, who developed second unrelated malignancies inside the field of both the conventional and the stereotactic irradiation within 13 months of completion of EBRT. One was a 48-year-old man with a right...
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