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Deviations from physiological pH (∼pH 7.2) as well as altered Ca 2+ signaling play important roles in immune disease and cancer. One of the most ubiquitous pathways for cellular Ca 2+ influx is the store-operated Ca 2+ entry (SOCE) or Ca 2+ release-activated Ca 2+ current (I CRAC ), which is activated upon depletion of intracellular Ca 2+ stores...
The store-operated, calcium release-activated calcium current I CRAC is activated by the depletion of inositol 1,4,5-trisphosphate (IP 3 )-sensitive stores. The significantly different dose–response relationships of IP 3 -mediated Ca 2+ release and CRAC channel activation indicate that I CRAC is activated by a functionally, and possibly physically, distinct...
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