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TRPM3 proteins assemble to Ca2+-permeable cation channels in the plasma membrane, which act as nociceptors of noxious heat and mediators of insulin and cytokine release. Here we show that TRPM3 channel activity is strongly dependent on intracellular Ca2+. Conceivably, this effect is attributed to the Ca2+ binding protein calmodulin, which binds to TRPM3 in a Ca2+-dependent manner. We identified five...
Transient receptor potential A1 channels are well‐known as chemosensors in neuronal cells. However, recent studies also point to non‐neuronal functions in epithelia. Here, we show that TRPA1 channels are expressed in epithelial MDCK II cells and contribute to Ca2+ influx and whole‐cell currents after stimulation with AITC. Stimulation of TRPA1 channels induced an immediate reduction of the transepithelial...
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