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Immunotherapy is a promising cancer therapeutic strategy. However, the “cold” tumor immune microenvironment (TIME), characterized by insufficient immune cell infiltration and immunosuppressive status, limits the efficacy of immunotherapy. Tumor vascular abnormalities due to defective pericyte coverage are gradually recognized as a profound determinant in “cold” TIME establishment by hindering immune...
Tumor Immunotherapy
Tumor vascular abnormalities is a profound determinant in the “cold” tumor immune microenvironment establishment by hindering immunotherapy efficacy. PDGFB@ZIF8‐RGD effectively induced tumor vascular normalization, by reprogramming the “cold” TIME to a “hot” tumor immune microenvironment and facilitated robust antitumor immunity. More in article number 2308638, Yongquan Qu, Jie...
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