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Purpose: We tested whether the adenosine A1 receptor agonist, R-PIA, suppressed torsade de pointes (TdP) induced by the delayed rectifier potassium channel blocker clofilium. Furthermore, we studied the underlying mechanism: β-adrenergic antagonism or ATP-sensitive K+ channel (IK-ATP) opening. Methods: In anesthetized rabbits, TdP was induced by simultaneous infusion of clofilium and the α1-adrenoceptor...
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