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AbstractObjective: To examine the effect of grapefruit juice on the metabolism of felodipine following intravenous and oral administration. Methods: The study had a randomised, four-way, crossover design in 12 healthy males. Single doses of felodipine were given as an intravenous infusion for 1h (1.5mg) or as an oral extended release (ER) tablet (10mg). Grapefruit juice (150ml) or water was ingested...
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