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Highly compacted DNA nanoparticles, composed of single molecules of plasmid DNA compacted with block copolymers of poly-l-lysine and 10kDa polyethylene glycol (CK 30 PEG 10k ), mediate effective gene delivery to the brain, eyes and lungs in vivo. Nevertheless, we found that CK 30 PEG 10k DNA nanoparticles are immobilized by mucoadhesive interactions in sputum that lines...
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