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OBJECTIVE: Cigarette smoke extracts (CSE) could promote esophageal squamous cell carcinoma (ESCC) through upregulation of cyclooxygenase‐2 (COX‐2) expression. Promoter methylation mediates the transcriptional modulation of the COX‐2 gene. The aim of the study was to explore whether COX‐2 promoter methylation regulated COX‐2 expression and functional activity in ESCC exposed to CSE.
METHODS: The...
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