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Target therapy for highly heterogeneous cancers represents a major clinical challenge due to the lack of recurrent therapeutic targets identified in these tumors. Herein, the authors report a tumor‐customized targeting photothermal therapy (PTT) strategy for highly heterogeneous cancers, by which 2D supramolecular self‐assembled nanodiscs are modified with tumor‐specific binding peptides identified...
Photothermal Therapy
In article number 2200179, Xuesheng Jiang, Xiaohua Yu, Zhaoming Ye, and co‐workers introduce a strategy of precise photothermal therapy for highly heterogenous cancers by a tumor‐customized 2D supramolecular nanodisc (T‐ND). By modifying Cy7‐TCF crystal with phage display derived tumor‐customized binding peptides, T‐ND shows excellent photothermal efficacy to ablate the tumor...
It is highly desired but still remains challenging to design a primary explosive‐based nanoparticle‐encapsulated conductive skeleton for the development of powerful yet safe energetic films employed in miniaturized explosive systems. Herein, a proof‐of‐concept electrochemical preparation of metal–organic frameworks (MOFs) derived porous carbon embedding copper‐based azide (Cu(N3)2 or CuN3, CA) nanoparticles...
Colloidal lithography provides a rapid and low‐cost approach to construct 2D periodic surface nanostructures. However, an impressive demonstration to prepare large‐area colloidal template is still missing. Here, a high‐efficient and flexible technique is proposed to fabricate self‐assembly monolayers consisting of orderly‐packed polystyrene spheres at air/water interface via ultrasonic spray. This...
Artificial intelligence vision systems (AIVSs) with information sensing, processing, and storage functions are increasingly gaining attention in the science and technology community. Although synapse phototransistor (SPT) is one of the essential components in AIVSs, solution‐processed large‐area photonic synapses that can detect and recognize multi‐wavelength light are highly desirable. One of the...
Selenium(Se)‐based solar cells (SSCs), known as one of the oldest solar cells, have regained intense attention due to the advantages of Se including direct bandgap, good stability, and single absorber. Among all kinds of device structures, conventional n‐i‐p SSCs with top organic hole transport layers (HTLs) show great potential since organic HTLs could be well‐designed to smoothly extract holes from...
Early diagnosis and timely intervention are key for the successful treatment of skin diseases like abnormal scars. This study introduces a nucleic‐acid‐based probe (i.e., molecular sprinkler) for the diagnosis and spontaneous regulation of the abnormal expression of fibrosis‐related mRNA in scar‐derived skin fibroblasts. Using mRNA encoding connective tissue growth factor (CTGF) as the model gene,...
In article number 1801905, Jinlong Shi, Rongqin Huang, Wei Shi, and co‐workers describe a novel drug‐loaded system, OPPD, which uses PEG and OMCN linked to the Pep22 polypeptide targeting the low‐density lipoprotein receptor, that can effectively cross the blood‐brain barrier and target glioma cells, exerting an outstanding therapeutic efficacy via both the near‐infrared photothermal and chemotherapeutic...
Accumulating studies have investigated the efficacy of receptor‐mediated delivery of hydrophobic drugs in glioma chemotherapy. Here, a delivery vehicle comprising polyethylene glycol (PEG) and oxidized nanocrystalline mesoporous carbon particles (OMCN) linked to the Pep22 polypeptide targeting the low‐density lipoprotein receptor (LDLR) is designed to generate a novel drug‐loaded system, designated...
Zeolitic imidazolate framework‐8 (ZIF‐8)‐derived N‐doped graphene analogous polyhedrons (ZNGs) obtained via the direct carbonation of ZIF‐8 are applied to photocatalytic hydrogen evolution for the first time. The contents of different types of nitrogen atoms in ZNGs can be fine‐tuned via the calcination temperature, which significantly influences the hydrogen evolution rate of the ZNGs.
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