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Due to its immunosuppressive properties, the cytokine transforming growth factor (TGF)-β has become a promising target in the experimental treatment of human malignant gliomas. Here, we report that the antifibrotic drug 5-methyl-1-phenyl-2-(1H)-pyridone (pirfenidone, PFD) elicits growth-inhibitory effects and reduces TGF-β 2 protein levels in human glioma cell lines. This reduction in TGF-β...
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