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Accumulating evidence has shown that individual commonly occurring single nucleotide polymorphisms (SNPs) are associated with the cancer risks. Hence, determining the disease-causing SNPs have become an important issue. In order to explore SNP-SNP interactions in breast cancer, we used a genetic algorithm (GA) to simultaneously analyze multiple independent SNPs, and to compute the difference between...
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) is useful in small-scale basic research studies of complex genetic diseases that are associated with single nucleotide polymorphism (SNP). Designing a feasible primer pair is an important work before performing PCR-RFLP for SNP genotyping. However, in many cases, restriction enzymes to discriminate the target SNP resulting...
Many association studies analyze the genotype frequencies of case and control data to predict susceptibility to diseases and cancers. An increasing number of studies has shown that the risk of getting diseases and cancers is associated with the co-occurrence of some contain single nucleotide polymorphisms (SNPs). Determining the disease-causing SNPs has become an important objective. In order to study...
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