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A major limitation of photodynamic therapy (PDT) for Barrett’s esophagus is the development of esophageal stricture. We developed an animal model of PDT-induced esophageal stricture to elucidate the mechanism of stricture development. Our studies began in a mouse but, due to its limitations, we advanced to a porcine model. In the mouse model, 62 mice were injected with Photofrin (2–10 mg/kg) 48...
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