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High consumption of irrational fixed‐dose combination (FDC) antibiotics may pose a threat of antimicrobial resistance. In India, ampicillin–cloxacillin was the second highest sold FDC antibiotic behind amoxicillin and clavulanic acid. There remain, however, questions about its efficacy and safety and a lack of regulatory approval. We undertook a literature review for ampicillin–cloxacillin to identify...