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Jaspolide B is a novel isomalabaricane-type triterpene isolated from sponge Jaspis sp. We investigated its effects on human hepatoma cells in this study. After 48h of incubation, jaspolide B inhibited the growth of Bel-7402 and HepG2 cells with IC 50 values of 29.1 and 29.5μM, respectively. Incubation with 0.5μM of jaspolide B caused time-dependent induction of apoptosis in up to 66.8% of...
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