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Central nervous system (CNS) innate immunity plays essential roles in infections, neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are the principal cells that mediate innate immunity in the CNS. Pattern recognition receptors (PRRs), expressed by astrocytes and microglia, sense pathogen-derived or endogenous ligands released by damaged cells and initiate the...
The study presents an analysis for geometrical errors in five axis CNC machine tools using virtual machining systems to increase accuracy in part manufacturing. Thus, efficiency of part production can be increased.
The beta-transus temperatures (𝑇𝛽) of graphene oxide (GO) reinforced high-temperature titanium alloy matrix composites were studied by metallography method. With the increase of GO content, 𝑇𝛽 increases linearly when the content of GO is 0 – 0.17 wt%, and then stays flat when the content is 0.17 – 0.23 wt%. The 𝑇𝛽 of the composite with only 0.17 wt% GO is up to 1132.5±2.5 ℃, which is 80 ℃ higher...
Understanding the ideal powder properties required for powder bed fusion additive manufacturing (PBF-AM) is essential to maximize the quality of the build and reduce the possibility of generating defects. To date, the testing techniques typically used to characterise powders in the metallurgy field are applied to PBF-AM. However, the results are commonly untranslatable to the PBF-AM process. In this...
Basalt cotton (BC) has a cotton-like structure due to the three-dimensional skeleton built by basalt fiber overlapping, which exhibit high flexibility. To explore the application of BC, hollow silica spheres (HSSs) were planted on the three-dimensional skeleton of BC by combining a sol-gel method and a sacrificial template method, to obtain HSS/BC composites. Scanning electron microscopy revealed...
Metabolomics has been increasingly applied in biomedical research and drug efficacy evaluation in the context of rapid advances in analytical instrumentation and bioinformatics. Metabolomics-based discovery will potentiate the drug development in many ways such as novel biomarkers discovery, precise clinical trial by stratifying patients, and evaluation of drug metabolism or toxicity. More translational...
Recently, Recurrent Neural Network (RNN) solutions for recommender systems (RS) are becoming increasingly popular. The insight is that, there exist some intrinsic patterns in the sequence of users' actions, and RNN has been proved to perform excellently when modeling sequential data. In traditional tasks such as language modeling, RNN solutions usually only consider the sequential order of objects...
Stressful incidents at work were examined using an open‐ended technique for the occupations. Meanwhile, the organizations are expecting much more from their employees as a consequence of the industry evolution. Higher demands and requirements have impacted the well-being of employees increasing the levels of occupational stress. The purpose of this study was to examine gender differences in response...
Background: MDR1 gene polymorphisms were demonstrated to be associated with interindividual variability of imatinib response for chronic myeloid leukemia (CML) patients in several studies; however, the results have been inconclusive. Materials & methods: To clarify the effect of common MDR1 variants on clinical response to imatinib, we performed a meta-analysis to quantify the accumulated information...
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