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Multiple oncogenic events are involved in the development of adult T‐cell leukaemia/lymphoma (ATL). Because CD28 plays a pivotal role in T‐cell activation, we focused on alterations of the CD28 gene in ATL. We found multiple genetic abnormalities related to CD28 among the 144 patients enrolled in the present study. These involved gene fusions with the cytotoxic T‐lymphocyte‐associated antigen 4 or...
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