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As a model for hormone-dependent breast cancer, we studied the MCF-7 cell line to examine differences in the stimulation of the inducible (i) and endothelial (e) nitric oxide synthase (NOS) and the role of 17β-estradiol (E 2 ).MCF-7 cells were stimulated with (a) E 2 (10 −8 M) and (b) a combination of different cytokines such as interleukin-1 beta (Il-1β), tumor necrosis factor...
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