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It is assumed that the regulation of cardiac endothelin (ET) receptor density is abnormal in heart diseases. From that perspective, an ET receptor radioligand is needed to assess ET receptor density in vivo. The nonpeptidyl ET A receptor antagonist PD 169390 was labelled with radioiodine to give a putative radioligand for SPECT. Labelling with [ 125 I]iodide and [ 123 I]iodide...
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