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ObjectiveMicrovascular hyperpermeability that occurs due to breakdown of the BBB is a major contributor of brain vasogenic edema, following IR injury. In microvascular endothelial cells, increased ROS formation leads to caspase‐3 activation following IR injury. The specific mechanisms, by which ROS mediates microvascular hyperpermeability following IR, are not clearly known. We utilized an OGD‐R in vitro...
Please cite this paper as: Sawant, Tharakan, Adekanbi, Hunter, Smythe and Childs (2011). Inhibition of VE‐Cadherin Proteasomal Degradation Attenuates Microvascular Hyperpermeability. Microcirculation18(1), 46–55.
AbstractObjective: VE‐cadherin, an integral component of the adherens junction complex, is processed through the endosome–lysosome pathway and proteasome system for degradation. Our objective...
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