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The resorption of alveolar bone in periodontitis and/or following tooth extraction results in a significant problem in an individual's oral health-related quality of life. Strategies employing growth factor proteins and/or stem cell-based therapy have been successfully used to regenerate alveolar bone augmentation/regeneration; however, cost-effectiveness issues illustrate the need for developing...
Recently, the binding sequence Ser-Val-Val-Tyr-Gly-Leu-Arg (SVVYGLR) was found adjacent to the RGD sequence in osteopontin, suggesting involvement in osteo-immune cross-talk. The aim of this study was to investigate bioactive functions of a synthetic SVVYGLR peptide in osteoprogenitor cells and osteoclasts, and to examine potential applications in bone regeneration. The SVVYGLR peptide significantly...
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