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Following myocardial infarction (MI), the left ventricle undergoes progressive dilatation and eccentric hypertrophy, i.eremodeling, which is greater in the adjacent than the remote region. The cellular mechanisms underlying these regional differences were studied. One (n=5) and 8 weeks (n=8) after anteroapical MI in sheep, cardiac myocytes were isolated from the adjacent and remote regions. At 8 weeks...
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