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We report a structure-activity model of chemicals with the potential to cause respiratory allergy developed through the CASE/-MultiCASE systems. Chemicals documented to elicit a decrease in FEV 1 of =<20% within 24 h of inhalation provocation challenge were used to form a learning set. Additional requirements for inclusion in the learning set were that chemicals had at least two contiguous...
Objectives: The clinical features, airway histology, and detection of hexamethylene diisocyanate (HDI) protein adducts in endobronchial biopsies from a patient with HDI asthma are described. Methods: Isocyanate asthma was diagnosed by history, methacholine challenge, acid workplace HDI challenge. Bronchoscopy was performed 24 h after challenge and immunohistochemical staining was performed. Results:...
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