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In this study, we report that cytoplasmic granules from in vivo and in vitro derived mouse mast cells (MCs) contain active granzyme B (gzmB) and caspase‐3, which is consistent with recent findings. Studying WT and gzmB‐deficient mice, we observed that BM‐derived MCs (BMMCs) from both strains contain cytosolic pro‐caspase‐3, but only WT BMMCs expressed active caspase‐3 limited to their secretory lysosomes...
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