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A series of novel thiadiazole amide derivatives have been synthesized and evaluated for inhibitory activities against Cdc25B and PTP1B. Most of them showed inhibitory activities against Cdc25B (IC 50 =1.18–8.01μg/mL) and PTP1B (IC 50 =0.85–8.75μg/mL), respectively. Moreover, compounds 5b and 4l were most potent with IC 50 values of 1.18 and 0.85μg/mL for Cdc25B and PTP1B, respectively,...
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