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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) possesses strong anti-cancer potential because of its ability to specifically kill cancer cells. However, clinical use of TRAIL is impeded by its short in vivo half-life and native TRIAL-resistant cancer cell populations. To overcome these limitations, we designed a multiple magnetic hyperthermia (MHT)-mediated TRAIL release system for...
Magnetic hyperthermia therapy (MHT) has been explored as an efficient and non-invasive treatment for cancer. However, the short retention time of magnetic nanoparticles localized within tumor targets hinders its potential for repeatable treatment. We report herein on the development of an injectable, biodegradable, thermosensitive and superparamagnetic iron oxide nanoparticle-loaded nanocapsule hydrogels...
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