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The pre‐Bötzinger complex (pre‐BötC) in the ventrolateral medulla oblongata is a presumed kernel of respiratory rhythmogenesis. Ca2+‐activated non‐selective cationic current is an essential cellular mechanism for shaping inspiratory drive potentials. Ca2+/calmodulin‐dependent protein kinase II (CaMKII), an ideal ‘interpreter’ of diverse Ca2+ signals, is highly expressed in neurons in mediating various...
J. Neurochem. (2012) 122, 923–933.
AbstractThe pre‐Bötzinger complex (pre‐BötC) in the ventrolateral medulla oblongata is critical for the generation of respiratory rhythm in mammals. Somatostatin (SST) and neurokinin 1 receptor (NK1R) immunoreactivity have been used as markers of the pre‐BötC. SST immunoreactivity almost completely overlaps with small fusiform NK1R‐immunoreactive (ir) neurons, the...
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