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Synergetic Prostate Cancer Therapies
In article number 2207077, Li Zhang, Yunjiao Zhang, Chaozhao Liang, and co‐workers propose intratumoral implantation of micromagnets to actively attract intravenously‐injected magnetic PEGylated manganese‐zinc ferrite nanocrystals (PMZFNs) from blood vessels into tumor tissue. PMZFNs exert relatively durable tumoricidal effects by inducing ferroptotic/immunogenic...
Therapeutic efficacy for prostate cancer is highly restricted by insufficient drug accumulation and the resistance to apoptosis and immunogenic cell death (ICD). Although enhanced permeability and retention (EPR) effect of magnetic nanomaterials could benefit from external magnetic field, it falls off rapidly with increased distance from magnet surface. Considering the deep location of prostate in...