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Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3′- and 4′-demethylnobiletin) and di-demethylation (3′,4′-didemethylnobiletin) metabolic pathway. Biological...
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