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Early studies in our laboratory suggested that in young (3–12 weeks of age) male spontaneously hypertensive rats (SHR), ingestion of a high NaCl diet exacerbates hypertension (Fig. 1), increases peripheral sympathetic nervous system activity and alters the norepinephrine (NE) content of a hypothalamic nucleus known to be involved blood pressure (BP) regulation (Winternitz et al, 1982a, b; Wyss et...
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