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The paramyxovirus P gene encodes accessory proteins antagonistic to interferon (IFN). Viral proteins responsible for the IFN antagonism, however, are distinct among paramyxoviruses. Here we determine bovine parainfluenza virus type 3 (bPIV3) IFN antagonists that suppress IFN-β production, and investigate the underlying molecular mechanism. Of bPIV3 P gene products, C and V proteins were found to suppress...
We here report a molecular basis for downregulation of interferon (IFN)-β production by V and C proteins of Sendai virus (SeV). The infection of HeLa cells with SeV poorly induced IFN-β even if the expression of C/C' was disrupted. In contrast, when the expression of C/C'/Y1/Y2 or V/W was disrupted, SeV infection strongly induced IFN-β production and significantly activated the interferon regulatory...
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