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Sendai virus (SeV) accessory protein C limits the generation of double‐stranded RNAs, defective interfering RNAs, or both, during viral transcription and replication, thereby limiting interferon‐β production. Our recent in vitro analyses on murine macrophage cell lines demonstrated that this protein also contributes to restricting macrophage function, including the production of nitric oxide (NO)...
Flavopiridol is a cyclin‐dependent kinase inhibitor and inhibits the growth of various cancer cells. The effect of flavopiridol on lipopolysaccharide (LPS)‐induced proinflammatory mediator production was examined in RAW 264.7 macrophage‐like cells. Flavopiridol significantly reduced the production of tumor necrosis factor‐α and, to a lesser extent, nitric oxide in LPS‐stimulated cells. Flavopiridol...
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