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The neurotoxicity of the amyloid-β peptide (Aβ) appears to be, at least in part, related to pathological activation of glutamate receptors by Aβ aggregates. However, the downstream signaling pathways leading to neurodegeneration are still incompletely understood. Hyperactivation of nitric oxide synthase (NOS) and increased nitric oxide (NO) production have been implicated in excitotoxic neuronal damage...
The effects of glutamate receptor antagonists on the toxicity of the β-amyloid peptide (Aβ 1–42 ) in embryonic chick retina were investigated. When used alone or in combination, the N-methyl-d-asparate antagonist, MK-801, the (±)-αamino-3-hydroxyl-5-methylisoxazole-4-propinic acid/kainate antagonist, DNQX, and the metabotropic receptor antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid, blocked...
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