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The hepatitis B virus × protein (HBx) of Hepatitis B virus activates AP-1 protein and causes the down regulation of PTEN (full name) and p53 leads to the tumor formation in liver. In this study, the interactions between DNA and AP-1 have been targeted by docking of natural compounds epigallocatechine gallate (EGCG), curcumin, luteoline, genistein, ellagic acid, resveratrol, lupeol, betulinic acid...
Alzheimer’s disease (AD) is caused by the accumulation of beta-amyloid (β-A) in the brain that forms amyloid plaque. β-A is an oligo-peptide consisting of 39–42 amino acid residues, produced by proteolytic cleavage of amyloid precursor protein by secretase enzymes. Evolutionary trace and protein family analysis of β-A indicates that C-terminal residues of β-A are highly conserved and hydrophobic in...
The Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase (pfSAHH) enzyme has been considered as a potential chemotherapeutic target against malaria due to the amino acid differences found on binding sites of pfSAHH related to human SAHH. It has been reported that noraristeromycin and some curcumin derivatives have potential binding with the largest cavity of pfSAHH, which is also related to the...
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