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Calcium channels derived from sarcoplasmic reticulum of frog skeletal muscle were fused with planar lipid bilayers. Fractional open times displayed two types of calcium dependence: (i) blockable channels showed a bell-shaped calcium dependence with an activation constant of 4.5 μM, a Hill coefficient for activation of 1.46 and a blocking constant of 226 μM, and (ii) non-blockable channels displayed...
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