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A malignant pleural effusion (MPE) from lung cancer represents stage IV disease and portends a poor prognosis. Routine mutational analysis of tissue samples is the standard of care in advanced lung cancer management because it has treatment implications. Sampling of MPE is minimally invasive, safe, repeatable, and provides both diagnostic and therapeutic value. Mutational analysis on MPE has been...
Platinum-based doublet chemotherapy is the traditional treatment of choice for advanced non-small cell lung cancer (NSCLC); however, the efficacy of these regimens has reached a plateau. Increasing evidence demonstrates that patients with sensitizing mutations in the epidermal growth factor receptor (EGFR) experience improved progression-free survival and response rates with first-line gefitinib or...
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