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We propose a de novo glycan display approach that combines metabolic labeling and a glycan‐caging strategy as a facile editing method for cell‐surface glycans. This method enables the introduction of antigen glycans onto cancer cells to induce immune responses through antibody recruiting. The caging strategy prevents the capture of α‐rhamnose (an antigen glycan) by endogenous antibodies during the...
Glycan Engineering. In their Communication (e202303750), Yoshiyuki Manabe, Koichi Fukase et al. report a glycan‐display approach that combines metabolic labeling and the glycan‐caging strategy for editing cell‐surface glycans. The method enables the introduction of antigen glycans onto cancer cells to induce immune responses.
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