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Direct contact with stromal cells protects chronic lymphocytic leukaemia (CLL) B cells from chemotherapy‐induced apoptosis in vitro. Blockade of CXCR4 signalling antagonizes stroma‐mediated interactions and restores CLL chemosensitivity. In vivo, administration of CXCR4 antagonists effectively mobilizes haematopoietic progenitor cells. Therefore, combinations of CXCR4 blockade and cytoreductive treatment...
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