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Lipid‐membrane‐targeting strategies hold great promise to develop broad‐spectrum antivirals. However, it remains a big challenge to identify novel membrane‐based targets of viruses and virus‐infected cells for development of precision targeted approaches. Here, it is discovered that viroporins, viral‐encoded ion channels, which have been reported to mediate release of hydrogen ions, trigger membrane...
Antiviral Strategies
A gradient pH‐sensitive (GPS) polymer is developed by Fuping You, Dan Lu, Zhiqiang Lin, and co‐workers in article number 2109580. In response to an acidified membrane, the GPS polymer with dye conjugation illuminates, targets, and lyses the envelope of viruses, resulting in leakage of viral nucleic acid and a broad‐spectrum activity of the GPS polymer against a variety of viruses...