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Cholera is a severe diarrheal disease that may spread rapidly. Vaccination is considered a valid measure against it. We developed a new vaccine candidate, IEM109, against Vibrio cholerae. To generate this candidate, a chromosomal fragment containing the TLC element, attB of the CTXΦ integration site, and RTX cluster responsible for the cytotoxic activity for mammalian cells was deleted through homologous...
The cholera toxin (CT) genes ctxAB are carried on a lysogenic phage of Vibrio cholerae, CTXΦ, which can transfer ctxAB between toxigenic and nontoxigenic strains of bacteria. This transfer may pose a problem when live oral cholera vaccine is given to people in epidemic areas, because the toxin genes can be reacquired by the vaccine strains. To address this problem, we have constructed a live vaccine...
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