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Patients with dilated cardiomyopathy (DCM) often have autoantibodies against cardiac antigens including the M2 muscarinic acetylcholine receptor (M2R). To elucidate the role of autoimmunity against M2R in disease development, we induced an immune response against M2R by adoptive transfer into Rag2–/– mice of splenocytes from M2R–/– mice immunized with a recombinant M2R protein. T lymphocytes transiently...
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