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Using an NMR based approach, employing both solution state and high resolution magic angle spinning (HR MAS) 1H NMR spectroscopy, in conjunction with an array of statistical methods, we report cerebral metabolic deficits in a mouse model of Batten disease (Cln3 null mutant mice). Batten disease is the most common progressive neurodegenerative disorder of childhood and is caused by mutations in the...
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