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Background Electrical stimulation is widely used in experimental pain research but it lacks selectivity towards small nociceptive fibers. When using standard surface patch electrodes and rectangular pulses, large fibers are activated at a lower threshold than small fibers. Pin electrodes have been designed for overcoming this problem by providing a higher current density in the upper epidermis where...
Background. The brain-gut interaction is important for the understanding of pain mechanisms related to gastroenterological diseases. Unfortunately little is known about the early cerebral events related to the processing of gut-evoked pain. The aims of this human study were (1) to investigate the early-evoked brain potentials (EPs) to painful sigmoid colon stimulation and (2) to evaluate the EPs evoked...
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