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We report five paediatric cases of portal vein thrombosis (PVT) occurring during chemotherapy, observed in two institutions over an 8-year time period. These children aged 2.5–15 years were treated for Burkitt’s lymphoma, Ewing’s tumour, small cell bone tumour or medulloblastoma. PVT was diagnosed on colour Doppler ultrasonography (US). In four patients, thrombosis occurred 2–45 days after severe...
La toxicite neurologique centrale des medicaments cytotoxiques est fonction de leur capacite a traverser la barriere hematoencephalique. Les medicaments diffusant aisement sont ceux dont la toxicite neurologique est la plus importante : alkylants (metabolites du cyclophosphamide et de l'ifosfamide, le thiotepa et le melphalan a fortes doses), busulfan, derives du platine, aracytine et methotrexate...
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