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Hypervariable region 1 (HVR1) of hepatitis C virus (HCV) shows striking genetic alterations, even within a period of several months, in patients with chronic hepatitis (CH). Recently, using our developed assay system for detection anti-HVR1 antibodies, we found that HVR1 acts as an immunological epitope, and that altered HVR1 variants can escape from pre-existing antibodies. This suggests that genetic...
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