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Objectives: The combination of Taxol with a platinum-based chemotherapy is now the standard first-line chemotherapy following surgical debulking in the treatment of ovarian cancer. Approximately 25% of patients fail this treatment and are deemed Taxol-platinum resistant. However, it is unclear if these patients are resistant to both drugs or to one drug that exhibits mechanistic dominance. We set...
Objective: Microtubule stabilization has been shown to be the pathway by which Taxol induces apoptosis. We undertook in vitro experiments to evaluate the effects of Taxol on the cytoskeleton of different ovarian cancer cells.Materials and Methods: One human ovarian cancer cell line (420) and the solid component from two recently isolated epithelial ovarian tumors (HS-1, HS-2) were cultured adherently...
Taxol is a novel chemotherapeutic agent used in the treatment of ovarian and breast carcinomas. Cells exposed to taxol accumulate in the radiosensitive G2/M phase of the cell cycle. In light of this observation, we undertook studies to determine whether taxol potentiates cellular responses to radiation in cervical cancer, a disease currently treated primarily with radiation therapy. Three actively...
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