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J. Neurochem. (2010) 115, 1309–1321.
AbstractCyclin‐dependent kinase (Cdk)5 is a proline‐directed Ser/Thr protein kinase that functions mainly in neurons and is activated by binding to a regulatory subunit, p35 or p39. Kinase activity is mainly determined by the amount of p35 available, which is controlled by a balance between synthesis and degradation. Kinase activity is also regulated by Cdk5 phosphorylation,...
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