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Objective
Endothelial nitric oxide synthase (eNOS) is a potential mediator of exercise‐induced hepatic mitochondrial adaptations.
Methods
Here, male and female hepatocyte‐specific eNOS knockout (eNOShep−/−) and intact hepatic eNOS (eNOSfl/fl) mice performed voluntary wheel‐running exercise (EX) or remained in sedentary cage conditions for 10 weeks.
Results
EX resolved the exacerbated hepatic...
Nonalcoholic fatty liver disease (NAFLD) is a major health problem, and its prevalence has increased in recent years, concurrent with rising rates of obesity and other metabolic diseases. Currently, there are no FDA‐approved pharmacological therapies for NAFLD, and lifestyle interventions, including weight loss and exercise, remain the cornerstones for treatment. Manipulating diet composition and...
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