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Experimental autoimmune uveitis (EAU) induced in male Lewis rats by immunization with bovine retinal S antigen, was prevented by prior intratesticular injection of S antigen. This protection is caused by the induction of systemic tolerance. This orchitic tolerance only requires the presence of the testis for 3 hours after intratesticular injection: orchitectomy after as little as 3 hours did not...
S-antigen, one of the most abundant soluble proteins in vertebrae rod photoreceptors, has been studied extensively because of its ability to induce experimental autoimmune uveoretinitis (EAU). In this study, the authors report the presence of a soluble protein in porcine retina, vitreous and ciliary body, which is similar but not identical to the bovine S-antigen. The porcine protein (52K-Da) has...
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