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Background Essential proteins are crucial for cellular life and thus, identification of essential proteins is an important topic and a challenging problem for researchers. Recently lots of computational approaches have been proposed to handle this problem. However, traditional centrality methods cannot fully represent the topological features of biological networks. In addition, identifying essential...
Annotation of protein functions plays an important role in understanding life at the molecular level. High‐throughput sequencing produces massive numbers of raw proteins sequences and only about 1% of them have been manually annotated with functions. Experimental annotations of functions are expensive, time‐consuming and do not keep up with the rapid growth of the sequence numbers. This motivates...
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