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Eine Echtzeit‐Beobachtung der Aktivität der Sauren Sphingomyelinase (ASM) ist notwendig zur Aufklärung ihrer Rolle in Lipid‐Signaltransduktionsprozessen. Mithilfe von Phosphorodichloridat‐Chemie gelang die Synthese von fluoreszierenden Phosphosphingolipiden mit der Fähigkeit zum FRET. Diese Sphingomyelin‐Analoga sind Substrate für die rekombinante humane ASM und ermöglichen die Verfolgung der ASM‐Aktivität...
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